Correlation of serum BDNF levels with hippocampal volumes in first episode medication free depressed patients.

Year
2010
Type(s)
Author(s)
EKER MEHMET ÇAĞDAŞ,KİTİŞ ÖMER,TANELİ FATMA,EKER DONAT ÖZLEM,OZAN EROL,YÜCEL ŞEFİK KAAN,COBURN KERRY,GÖNÜL ALİ SAFFET
Source
European Archives of Psychiatry and Clinical Neuroscience, 260(7), 527-533.
Url
https://doi.org/10.1007/s00406-010-0110-5

The hippocampus seems to be affected in MDD, and brain-derived neurotrophic factor (BDNF) has positive effects on neurogenesis within the hippocampus. Although there are inconsistencies among study results, a smaller hippocampal volume in depressed patients is thought to be related to the pathophysiology of the disease. We looked at the correlation between serum BDNF (sBDNF) levels and hippocampal volumes (HCV) of first-episode MDD patients (18 female, 7 male; mean age = 32.1 ± 9.3) and healthy controls (17 female, 5 male; mean age = 29.7 ± 6.4). Region of interest analysis was conducted on the images acquired via MRI. sBDNF levels and HCV correlated only in the MDD group (right: r = 0.46, P = 0.02; left: r = 0.47, P = 0.02); however, HCV did not differ between MDD patients and healthy controls (right: F = 2.45, df = 1.46, P > 0.05; left: F = 0.05, df = 1.46, P > 0.05). BDNF may be a factor underlying HCV differences between MDD and healthy control subjects, which become apparent as severe and multiple episodes are experienced.